Rho-kinase-mediated Ca -independent contraction in rat embryo fibroblasts
نویسندگان
چکیده
Daniel A. Emmert,* Judy A. Fee,* Zoe M. Goeckeler, Jeremy M. Grojean, Tetsuro Wakatsuki, Elliot L. Elson, B. Paul Herring, Patricia J. Gallagher, and Robert B. Wysolmerski Departments of Pathology, Saint Louis University School of Medicine, St. Louis 63104; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, Missouri 63110; and Department of Physiology, Indiana University School of Medicine, Indianapolis, Indiana 46202
منابع مشابه
Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts.
Thus far, determining the relative contribution of Ca2+/calmodulin-dependent myosin light chain kinase (MLCK) and Ca2+-independent Rho-kinase pathways to myosin II activation and contraction has been difficult. In this study, we characterize the role of Rho-kinase in a rat embryo fibroblast cell line (REF-52), which contains no detectable MLCK. No endogenous MLCK could be detected in REF-52 cel...
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